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As of April 2006, there are more than 30 preventive AIDS vaccine candidates in early stages of human clinical trials in approximately two dozen countries around the world. International AIDS Vaccine Initiative (IAVI) partnerships have supported the development and placement of two novel candidate vaccines in international trials in the past 14 months. IAVI has also entered into a multi-partner, multi-country trial of a prime-boost combination of two vaccines, IAVI V001.

IAVI and collaborators are currently conducting trials in India, Kenya, Rwanda, Uganda, South Africa, and the United States to evaluate the safety and immunogenicity of vaccine candidates. A trial in Pune, India – conducted by the Indian Council of Medical Research (ICMR), the National AIDS Control Organization (NACO), and IAVI – marks the country’s first AIDS vaccine trial. Initiated in February 2005, the partners have recently completed the recruitment and vaccination stages of the study. International vaccine organizations and private sector companies, such as HIV Vaccine Trials Network, National Institute of Allergy and Infectious Disease, Merck, Wyeth, and Guangxi Center for Disease Control have also begun Phase I studies in Peru, Kenya, Thailand, Brazil, and China.

The different trials involve 45 to 104 healthy volunteers who demonstrate full understanding of the study. In addition to monitoring trial participants to determine the safety of the vaccine product, during this stage of research, investigators also analyze blood samples to see if any immune response to the vaccine can be detected.

For more information about the vaccines visit http://www.iavireport.org/trialsdb/